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Gastroenterology 135 , 689698 (2008)

Diagnostic values can lie in a grey area here and still problems can arise

The neonatal Fc receptor (FcRn) recycling modulates half-life (albumin as a covariate), and anti-drug antibodies (ADAs) can accelerate clearance by forming immune complexes (Roopenian and Akilesh 2007

Furthermore, in a mouse model of RA, the icariin-induced upregulation of Nrf2 and TRIB1 significantly ameliorated joint damage, further confirming the efficacy of icariin [153]